6G31
Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Geranylgeranyl pyrophosphate synthase | polymer | 307 | 35484.4 | 12 | UniProt (O95749) Pfam (PF00348) | Homo sapiens (Human) | GGPPSase,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Farnesyltranstransferase,Geranylgeranyl diphosphate synthase,Geranyltranstransferase |
| 2 | AB, CA, EB, GA, KA... (K, E, L, F, G...) | ZOLEDRONIC ACID | non-polymer | 272.1 | 12 | Chemie (ZOL) | |||
| 3 | AA, BA, BB, CB, DA... (D, K, E, L, F...) | MAGNESIUM ION | non-polymer | 24.3 | 36 | Chemie (MG) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 300 (UniProt: O95749)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gln 109 | Pro 109 | conflict |
| Tyr 188 | Asp 188 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 425812.4 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 4140.1 | |
| All* | Total formula weight | 429952.5 |
