6G1X
CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interferon-induced helicase C domain-containing protein 1 | polymer | 696 | 80057.7 | 1 | UniProt (Q8R5F7) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) In PDB | Mus musculus (Mouse) | Helicase with 2 CARD domains,Helicard,Interferon induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,RIG-I-like receptor 2,RLR-2 |
2 | X | RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') | polymer | 15 | 4767.9 | 1 | Pseudomonas phage phi6 | ||
3 | Y | RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') | polymer | 15 | 4807.9 | 1 | Pseudomonas phage phi6 | ||
4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 307 - 1020 (UniProt: Q8R5F7)
PDB | External Database | Details |
---|---|---|
- | Asp 646 | deletion |
- | Lys 647 | deletion |
- | Ser 648 | deletion |
- | Asp 649 | deletion |
- | Asp 650 | deletion |
- | Glu 651 | deletion |
- | Ala 652 | deletion |
- | Ser 653 | deletion |
- | Ser 654 | deletion |
- | Cys 655 | deletion |
- | Asn 656 | deletion |
- | Asp 657 | deletion |
- | Gln 658 | deletion |
- | Leu 659 | deletion |
- | Lys 660 | deletion |
- | Gly 661 | deletion |
- | Asp 662 | deletion |
- | Val 663 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 89633.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 65.4 | |
All* | Total formula weight | 89698.9 |