6G0R

Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A peptide (K775ac/K778ac)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Bromodomain-containing protein 4	polymer	127	15099.4	1	UniProt (O60885) Pfam (PF00439) In PDB	Homo sapiens (Human)	Protein HUNK1
2	C	DNA-directed RNA polymerase II subunit RPB1	polymer	11	1221.4	1	UniProt (P24928) In PDB	Homo sapiens	RNA polymerase II subunit B1,DNA-directed RNA polymerase II subunit A,DNA-directed RNA polymerase III largest subunit,RNA-directed RNA polymerase II subunit RPB1
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4		water	water		18.0	145	Chemie (HOH)

Sequence modifications

A: 42 - 168 (UniProt: O60885)

PDB	External Database	Details
Met 43	Thr 43	conflict

C: 772 - 782 (UniProt: P24928)

PDB	External Database	Details
Tyr 782	Ser 782	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	16320.7
Non-Polymers*	Number of molecules	1
	Total formula weight	62.1
All*	Total formula weight	16382.8

*Water molecules are not included.