6G0R
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A peptide (K775ac/K778ac)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B (C) | DNA-directed RNA polymerase II subunit RPB1 | polymer | 11 | 1221.4 | 1 | UniProt (P24928) | Homo sapiens | RNA polymerase II subunit B1,DNA-directed RNA polymerase II subunit A,DNA-directed RNA polymerase III largest subunit,RNA-directed RNA polymerase II subunit RPB1 |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
C: 772 - 782 (UniProt: P24928)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | Thr 43 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Tyr 782 | Ser 782 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 16320.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 62.1 | |
| All* | Total formula weight | 16382.8 |
