6FXX

Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Gal, Hg2+ Soak

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	polymer	718	82784.4	1	UniProt (O60568) Pfam (PF25342) Pfam (PF25238) Pfam (PF03171)	Homo sapiens (Human)	Lysyl hydroxylase 3,LH3
2	B (B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
4	D, E, F (A)	MERCURY (II) ION	non-polymer		200.6	3	Chemie (HG) PubChem (26623)
5	G (A)	2-OXOGLUTARIC ACID	non-polymer		146.1	1	Chemie (AKG) PubChem (51)
6	H (A)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	1	Chemie (UDP) PubChem (1158) PubChem (6031) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (53486216) PubChem (60098857) PubChem (57448939) PubChem (3084486) PubChem (91746160) PubChem (6101632) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) PubChem (6604175) PubChem (11811538) PubChem (12049241)
7	I (A)	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN) PubChem (27854)
8	J, K (A)	FE (II) ION	non-polymer		55.8	2	Chemie (FE2) PubChem (27284)
9	L (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 25 - 738 (UniProt: O60568)

PDB	External Database	Details
Ser 24	-	expression tag
Ala 739	-	expression tag
Ala 740	-	expression tag
Ala 741	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	82784.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	10
	Total formula weight	1632.0
All*	Total formula weight	84840.8

*Water molecules are not included.