6FXV
Crystal structure of ERK2 in complex with an adenosine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 1 | polymer | 364 | 42311.7 | 1 | UniProt (P63086) Pfam (PF00069) In PDB | Rattus norvegicus (Norway rat) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | A | azanylidene-[[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[2-oxidanylidene-2-(prop-2-ynylamino)ethyl]sulfanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylimino]azanium | non-polymer | 420.4 | 1 | Chemie (E9W) | |||
| 5 | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence modifications
A: 1 - 358 (UniProt: P63086)
| PDB | External Database | Details |
|---|---|---|
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42311.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 750.9 | |
| All* | Total formula weight | 43062.6 |
