6FUI
Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Complement factor D | polymer | 232 | 24739.1 | 1 | UniProt (P00746) Pfam (PF00089) | Homo sapiens (Human) | Adipsin,C3 convertase activator,Properdin factor D |
| 2 | B (A) | (1~{R},2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]cyclohexane-1-carboxylic acid | non-polymer | 391.5 | 1 | Chemie (E7W) | |||
| 3 | C (A) | water | water | 18.0 | 317 | Chemie (HOH) |
Sequence modifications
A: 16 - 243 (UniProt: P00746)
| PDB | External Database | Details |
|---|---|---|
| Ser 244 | - | expression tag |
| Ala 245 | - | expression tag |
| Ala 246 | - | expression tag |
| Ala 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24739.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 391.5 | |
| All* | Total formula weight | 25130.6 |
