6FRX
PKA variant as Aurora B mimic in complex with a dianilinopyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 351 | 40856.5 | 1 | UniProt (P17612) Pfam (PF00069) In PDB | Homo sapiens (Human) | PKA C-alpha |
| 2 | B | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P61925) In PDB | Homo sapiens | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 3 | A | ~{N}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl)amino]phenyl]prop-2-enamide | non-polymer | 365.8 | 1 | Chemie (E3Z) | |||
| 4 | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P17612)
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Lys 48 | conflict |
| Gln 95 | Leu 96 | conflict |
| Leu 120 | Met 121 | conflict |
| Ala 123 | Val 124 | conflict |
| Lys 181 | Gln 182 | conflict |
| Ala 183 | Thr 184 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43082.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.8 | |
| All* | Total formula weight | 43448.7 |
