6FR2
Soluble epoxide hydrolase in complex with LK864
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional epoxide hydrolase 2 | polymer | 346 | 39648.5 | 1 | UniProt (P34913) Pfam (PF00561) | Homo sapiens (Human) | |
| 2 | B (A) | 1-[(4~{S})-9-propan-2-ylsulfonyl-1-oxa-9-azaspiro[5.5]undecan-4-yl]-3-[[4-(trifluoromethyloxy)phenyl]methyl]urea | non-polymer | 493.5 | 1 | Chemie (E3N) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 222 - 555 (UniProt: P34913)
| PDB | External Database | Details |
|---|---|---|
| Met 219 | - | initiating methionine |
| Ala 220 | - | expression tag |
| Ser 221 | - | expression tag |
| Leu 556 | - | expression tag |
| Leu 557 | - | expression tag |
| Glu 558 | - | expression tag |
| His 559 | - | expression tag |
| His 560 | - | expression tag |
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| His 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39648.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 517.8 | |
| All* | Total formula weight | 40166.4 |
