6FNI
Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with NVP-BHG712
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ephrin type-B receptor 4 | polymer | 297 | 33488.4 | 1 | UniProt (P54760) Pfam (PF07714) | Homo sapiens (Human) | Hepatoma transmembrane kinase,Tyrosine-protein kinase TYRO11 |
| 2 | B (A) | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | non-polymer | 503.5 | 1 | Chemie (DXH) | |||
| 3 | C (A) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A: 598 - 892 (UniProt: P54760)
| PDB | External Database | Details |
|---|---|---|
| Gly 596 | - | expression tag |
| Met 597 | - | expression tag |
| Glu 774 | Tyr 774 | engineered mutation |
| Val 803 | Ala 803 | engineered mutation |
| Ile 870 | Val 870 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33488.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 503.5 | |
| All* | Total formula weight | 33991.8 |
