6FNH
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with a pyrazolo[3,4-d]pyrimidine fragment of NVP-BHG712
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Ephrin type-A receptor 2 | polymer | 306 | 34462.8 | 3 | UniProt (P29317) Pfam (PF07714) | Homo sapiens (Human) | Epithelial cell kinase,Tyrosine-protein kinase receptor ECK |
| 2 | D, P, U (A, B, C) | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 226.2 | 3 | Chemie (DXK) | |||
| 3 | E, F, G, H, I... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | X, Y, Z (A, B, C) | water | water | 18.0 | 646 | Chemie (HOH) |
Sequence modifications
A, B, C: 596 - 900 (UniProt: P29317)
| PDB | External Database | Details |
|---|---|---|
| Gly 595 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 103388.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1733.9 | |
| All* | Total formula weight | 105122.4 |
