6FI3

Crystal structure of ERK2 in complex with an adenosine derivative

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 1	polymer	364	42235.5	1	UniProt (P63086) Pfam (PF00069) In PDB	Rattus norvegicus (Norway Rat)	MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
2	A	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	A	(2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-(azanyloxymethyl)oxolane-3,4-diol	non-polymer		282.3	1	Chemie (DJ2)
5		water	water		18.0	328	Chemie (HOH)

Sequence modifications

A: 1 - 358 (UniProt: P63086)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42235.5
Non-Polymers*	Number of molecules	5
	Total formula weight	612.7
All*	Total formula weight	42848.3

*Water molecules are not included.