6FFT

Neutron structure of human transthyretin (TTR) S52P mutant in complex with tafamidis at room temperature to 2A resolution (quasi-Laue)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transthyretin	polymer	130	14046.7	2	UniProt (P02766) Pfam (PF00576)	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	C, D (A, B)	2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid	non-polymer		308.1	2	Chemie (3MI)
3	E, F (A, B)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A, B: 1 - 127 (UniProt: P02766)

PDB	External Database	Details
Gly -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Pro 52	Ser 72	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28093.5
Non-Polymers*	Number of molecules	2
	Total formula weight	616.2
All*	Total formula weight	28709.7

*Water molecules are not included.