6FFI

Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5	polymer	444	49859.6	1	UniProt (P41594) UniProt (P00720) Pfam (PF00003) Pfam (PF00959)	Homo sapiens (Human)	mGluR5,Lysis protein,Lysozyme,Muramidase,mGluR5
2	B, C, D, E, F... (A)	OLEIC ACID	non-polymer		282.5	7	Chemie (OLA)	Enterobacteria phage T4
3	G (A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
4	J (A)	2-[2-(3-methoxyphenyl)ethynyl]-6-methyl-pyridine	non-polymer		223.3	1	Chemie (D8B)
5	K (A)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

A: 569 - 678 (UniProt: P41594)

PDB	External Database	Details
Ala 566	-	expression tag
Ala 567	-	expression tag
Ser 568	-	expression tag
Ala 579	Glu 579	engineered mutation
Tyr 667	Asn 667	engineered mutation
Ala 669	Ile 669	engineered mutation
Met 675	Gly 675	engineered mutation

A: 679 - 839 (UniProt: P00720)

PDB	External Database	Details
Gly 689	Arg 12	conflict
Thr 731	Cys 54	conflict
Ala 774	Cys 97	conflict
Arg 814	Ile 137	conflict

A: 840 - 996 (UniProt: P41594)

PDB	External Database	Details
Ala 902	Thr 742	engineered mutation
Ala 913	Ser 753	engineered mutation
Ala 997	-	expression tag
Ala 998	-	expression tag
Ala 999	-	expression tag
His 1000	-	expression tag
His 1001	-	expression tag
His 1002	-	expression tag
His 1003	-	expression tag
His 1004	-	expression tag
His 1005	-	expression tag
His 1006	-	expression tag
His 1007	-	expression tag
His 1008	-	expression tag
His 1009	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49859.6
Non-Polymers*	Number of molecules	9
	Total formula weight	2395.7
All*	Total formula weight	52255.3

*Water molecules are not included.