6FEG

Solution Structure of CaM/Kv7.2-hAB Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Potassium voltage-gated channel subfamily KQT member 2,Potassium voltage-gated channel subfamily KQT member 2	polymer	115	13599.5	1	UniProt (O43526)	Homo sapiens (Human)	KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2,KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2
2	B (B)	Calmodulin-1	polymer	149	16852.5	1	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (Human)	Calmodulin
3	C, D (B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A: 326 - 372 (UniProt: O43526)

PDB	External Database	Details
Met 1	-	initiating methionine
Ser 2	-	expression tag
Tyr 3	-	expression tag
Tyr 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Asp 11	-	expression tag
Tyr 12	-	expression tag
Asp 13	-	expression tag
Ile 14	-	expression tag
Pro 15	-	expression tag
Thr 16	-	expression tag
Thr 17	-	expression tag
Glu 18	-	expression tag
Asn 19	-	expression tag
Leu 20	-	expression tag
Tyr 21	-	expression tag
Phe 22	-	expression tag
Gln 23	-	expression tag
Gly 24	-	expression tag
Ala 25	-	expression tag
Met 26	-	expression tag
Gly 310	-	linker
Ile 311	-	linker
Leu 312	-	linker
Gly 313	-	linker
Ser 314	-	linker
Gly 315	-	linker

A: 502 - 532 (UniProt: O43526)

PDB	External Database	Details
Arg 373	-	linker
Gly 392	-	linker
Leu 393	-	linker
Leu 548	-	linker
Asp 549	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	30452.1
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	30532.2

*Water molecules are not included.