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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6FEC

Human cap-dependent 48S pre-initiation complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(1)		Eukaryotic translation initiation factor 3 subunit Apolymer1362164902.71Homo sapiens (Human)eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185
2B
(2)		Eukaryotic translation initiation factor 3 subunit Cpolymer84397923.51Homo sapiens (Human)eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110
3C
(3)		Eukaryotic translation initiation factor 3 subunit Epolymer44552281.61UniProt (P60228)
Pfam (PF09440)
Pfam (PF01399)
Pfam (PF21357)		Homo sapiens (Human)eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48
4D
(4)		Eukaryotic translation initiation factor 3 subunit Fpolymer36437846.71Homo sapiens (Human)eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47
5E
(5)		Eukaryotic translation initiation factor 3 subunit Hpolymer35239952.31Homo sapiens (Human)eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit
6F
(6)		Eukaryotic translation initiation factor 3 subunit Kpolymer21825129.71UniProt (Q9UBQ5)
Pfam (PF10075)		Homo sapiens (Human)eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28
7G
(7)		Eukaryotic translation initiation factor 3 subunit Lpolymer56466804.81UniProt (Q9Y262)
Pfam (PF10255)		Homo sapiens (Human)eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein
8H
(8)		Eukaryotic translation initiation factor 3 subunit Mpolymer37442555.81UniProt (Q7L2H7)
Pfam (PF01399)
Pfam (PF18005)		Homo sapiens (Human)eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1
9I
(9)		EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT Dpolymer36842203.61Homo sapiens
10J
(A)		18S ribosomal RNApolymer1776572789.81Homo sapiens
11K
(F)		Messenger RNA (26-MER)polymer268239.01Homo sapiens (Human)
12L
(G)		40S ribosomal protein S11polymer15818468.81UniProt (P62280)
Pfam (PF16205)
Pfam (PF00366)		Homo sapiens (Human)Small ribosomal subunit protein uS17
13M
(H)		40S ribosomal protein S16polymer14115975.81UniProt (P62249)
Pfam (PF00380)		Homo sapiens (Human)Small ribosomal subunit protein uS9
14N
(I)		40S ribosomal protein S4, X isoformpolymer26329658.91UniProt (P62701)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Homo sapiens (Human)SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4
15O
(J)		40S ribosomal protein S29polymer536364.41UniProt (P62273)
Pfam (PF00253)		Homo sapiens (Human)Small ribosomal subunit protein uS14
16P
(K)		40S ribosomal protein S9polymer18221266.21UniProt (P46781)
Pfam (PF00163)
Pfam (PF01479)		Homo sapiens (Human)Small ribosomal subunit protein uS4
17Q
(L)		40S ribosomal protein S18polymer13716170.81UniProt (P62269)
Pfam (PF00416)		Homo sapiens (Human)Ke-3,Ke3,Small ribosomal subunit protein uS13
18R
(N)		Transfer RNA (75-MER)polymer7524231.51GenBank (174924)Homo sapiens
19S
(P)		Eukaryotic translation initiation factor 2 subunit 1polymer26630633.31Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha
20T
(Q)		40S ribosomal protein S23polymer14215757.61UniProt (P62266)
Pfam (PF00164)		Homo sapiens (Human)Small ribosomal subunit protein uS12
21U
(R)		40S ribosomal protein S19polymer14115812.31Homo sapiens (Human)Small ribosomal subunit protein eS19
22V
(S)		Eukaryotic translation initiation factor 2 subunit 3polymer42245862.41UniProt (P41091)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF09173)		Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX
23W
(U)		40S ribosomal protein S5polymer19121525.91UniProt (P46782)
Pfam (PF00177)		Homo sapiens (Human)Small ribosomal subunit protein uS7
24X
(V)		40S ribosomal protein S30polymer596741.01UniProt (P62861)
Pfam (PF04758)		Homo sapiens (Human)Small ribosomal subunit protein eS30
25Y
(W)		40S ribosomal protein S25polymer758526.11UniProt (P62851)
Pfam (PF03297)		Homo sapiens (Human)Small ribosomal subunit protein eS25
26Z
(X)		40S ribosomal protein S7polymer19021716.41UniProt (P62081)
Pfam (PF01251)		Homo sapiens (Human)Small ribosomal subunit protein eS7
27AA
(Y)		40S ribosomal protein S27polymer849480.21UniProt (P42677)
Pfam (PF01667)		Homo sapiens (Human)Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27
28BA
(Z)		40S ribosomal protein S13polymer15017128.21UniProt (P62277)
Pfam (PF08069)
Pfam (PF00312)		Homo sapiens (Human)Small ribosomal subunit protein uS15
29CA
(a)		40S ribosomal protein S15apolymer12914734.41UniProt (P62244)
Pfam (PF00410)		Homo sapiens (Human)Small ribosomal subunit protein uS8
30DA
(b)		40S ribosomal protein S21polymer828896.11Homo sapiens (Human)Small ribosomal subunit protein eS21
31EA
(c)		40S ribosomal protein S2polymer22624814.31Homo sapiens (Human)40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5
32FA
(d)		EUKARYOTIC TRANSLATION INITIATION FACTOR 2 BETA SUBUNIT (eIF2-Beta)polymer172103.41Homo sapiens
33GA
(e)		40S ribosomal protein S17polymer12614579.01UniProt (P08708)
Pfam (PF00833)		Homo sapiens (Human)Small ribosomal subunit protein eS17
34HA
(f)		40S ribosomal protein SApolymer20823360.81UniProt (P08865)
Pfam (PF00318)		Homo sapiens (Human)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2
35IA
(g)		40S ribosomal protein S3polymer22725158.51UniProt (P23396)
Pfam (PF07650)
Pfam (PF00189)		Homo sapiens (Human)Small ribosomal subunit protein uS3
36JA
(h)		40S ribosomal protein S20polymer10411765.91UniProt (P60866)
Pfam (PF00338)		Homo sapiens (Human)Small ribosomal subunit protein uS10
37KA
(i)		40S ribosomal protein S3apolymer21524944.41UniProt (P61247)
Pfam (PF01015)		Homo sapiens (Human)Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1
38LA
(j)		40S ribosomal protein S14polymer13614544.71UniProt (P62263)
Pfam (PF00411)		Homo sapiens (Human)Small ribosomal subunit protein uS11
39MA
(k)		40S ribosomal protein S26polymer9911315.41Homo sapiens (Human)Small ribosomal subunit protein eS26
40NA
(l)		40S ribosomal protein S28polymer647263.41UniProt (P62857)
Pfam (PF01200)		Homo sapiens (Human)Small ribosomal subunit protein eS28
41OA
(m)		Receptor of activated protein C kinase 1polymer31334669.11UniProt (P63244)
Pfam (PF00400)		Homo sapiens (Human)Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
42PA
(n)		40S ribosomal protein S15polymer12715151.91UniProt (P62841)
Pfam (PF00203)		Homo sapiens (Human)RIG protein,Small ribosomal subunit protein uS19
43QA
(o)		40S ribosomal protein S8polymer20623902.91UniProt (P62241)
Pfam (PF01201)		Homo sapiens (Human)Small ribosomal subunit protein eS8
44RA
(p)		Ubiquitin-40S ribosomal protein S27apolymer718358.91UniProt (P62979)
Pfam (PF01599)		Homo sapiens (Human)Ubiquitin carboxyl extension protein 80
45SA
(q)		40S ribosomal protein S6polymer23727471.51UniProt (P62753)
Pfam (PF01092)		Homo sapiens (Human)Phosphoprotein NP33,Small ribosomal subunit protein eS6
46TA
(r)		40S ribosomal protein S12polymer12413766.11UniProt (P25398)
Pfam (PF01248)		Homo sapiens (Human)Small ribosomal subunit protein eS12
47UA
(s)		40S ribosomal protein S24polymer13115189.01UniProt (P62847)
Pfam (PF01282)		Homo sapiens (Human)Small ribosomal subunit protein eS24
48VA
(t)		40S ribosomal protein S10polymer9811774.01UniProt (P46783)
Pfam (PF03501)		Homo sapiens (Human)Small ribosomal subunit protein eS10
49WA
(u)		Eukaryotic translation initiation factor 4Bpolymer63672324.81UniProt (P23588)
Pfam (PF00076)		Homo sapiens (Human)eIF-4B
50XA
(w)		Eukaryotic translation initiation factor 3 subunit Bpolymer1121124402.31Homo sapiens (Human)eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116
51AB, BB, CB, DB, EB...
(A, H, U, j, l...)		waterwater18.0415Chemie (HOH)
Sequence modifications
6: 1 - 218 (UniProt: Q9UBQ5)
PDBExternal DatabaseDetails
Thr 166Ser 166conflict
Met 172Val 172conflict
7: 1 - 564 (UniProt: Q9Y262)
PDBExternal DatabaseDetails
Val 13Ala 13conflict
Arg 53Lys 53conflict
Thr 117Ala 117conflict
Ala 151Glu 151conflict
Ser 430Asn 430conflict
I: 1 - 263 (UniProt: P62701)
PDBExternal DatabaseDetails
Ser 25Gly 25conflict
Lys 51Arg 51conflict
Ala 78Thr 78conflict
Met 156Val 156conflict
V: 75 - 133 (UniProt: P62861)
PDBExternal DatabaseDetails
Val 83Ala 9conflict
Leu 91Pro 17conflict
Arg 102Lys 28conflict
g: 1 - 227 (UniProt: P23396)
PDBExternal DatabaseDetails
Ser 195Thr 195conflict
i: 19 - 233 (UniProt: P61247)
PDBExternal DatabaseDetails
His 136Arg 136conflict
Cys 146Arg 146conflict
n: 4 - 130 (UniProt: P62841)
PDBExternal DatabaseDetails
Ser 46Asn 46conflict
o: 2 - 207 (UniProt: P62241)
PDBExternal DatabaseDetails
Gly 47Arg 47conflict
s: 3 - 133 (UniProt: P62847)
PDBExternal DatabaseDetails
Gln 41Arg 41conflict
u: -94 - 516 (UniProt: P23588)
PDBExternal DatabaseDetails
Met -119-initiating methionine
Ser -118-expression tag
Tyr -117-expression tag
Tyr -116-expression tag
His -115-expression tag
His -114-expression tag
His -113-expression tag
His -112-expression tag
His -111-expression tag
His -110-expression tag
Asp -109-expression tag
Tyr -108-expression tag
Asp -107-expression tag
Ile -106-expression tag
Pro -105-expression tag
Thr -104-expression tag
Thr -103-expression tag
Glu -102-expression tag
Asn -101-expression tag
Leu -100-expression tag
Tyr -99-expression tag
Pro -98-expression tag
Gln -97-expression tag
Gly -96-expression tag
Ala -95-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains50
Total formula weight2006440.2
All*Total formula weight2006440.2
*Water molecules are not included.

246704

PDB entries from 2025-12-24

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