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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6FEC

Human cap-dependent 48S pre-initiation complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
11Eukaryotic translation initiation factor 3 subunit Apolymer1362164902.71Homo sapiens (Human)eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185
22Eukaryotic translation initiation factor 3 subunit Cpolymer84397923.51Homo sapiens (Human)eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110
33Eukaryotic translation initiation factor 3 subunit Epolymer44552281.61UniProt (P60228)
Pfam (PF09440)
Pfam (PF01399)
Pfam (PF21357)
In PDB		Homo sapiens (Human)eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48
44Eukaryotic translation initiation factor 3 subunit Fpolymer36437846.71Homo sapiens (Human)eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47
55Eukaryotic translation initiation factor 3 subunit Hpolymer35239952.31Homo sapiens (Human)eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit
66Eukaryotic translation initiation factor 3 subunit Kpolymer21825129.71UniProt (Q9UBQ5)
Pfam (PF10075)
In PDB		Homo sapiens (Human)eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28
77Eukaryotic translation initiation factor 3 subunit Lpolymer56466804.81UniProt (Q9Y262)
Pfam (PF10255)
In PDB		Homo sapiens (Human)eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein
88Eukaryotic translation initiation factor 3 subunit Mpolymer37442555.81UniProt (Q7L2H7)
Pfam (PF01399)
Pfam (PF18005)
In PDB		Homo sapiens (Human)eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1
99EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT Dpolymer36842203.61Homo sapiens
10A18S ribosomal RNApolymer1776572789.81Homo sapiens
11FMessenger RNA (26-MER)polymer268239.01Homo sapiens (Human)
12G40S ribosomal protein S11polymer15818468.81UniProt (P62280)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS17
13H40S ribosomal protein S16polymer14115975.81UniProt (P62249)
Pfam (PF00380)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS9
14I40S ribosomal protein S4, X isoformpolymer26329658.91UniProt (P62701)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)
Pfam (PF08071)
In PDB		Homo sapiens (Human)SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4
15J40S ribosomal protein S29polymer536364.41UniProt (P62273)
Pfam (PF00253)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS14
16K40S ribosomal protein S9polymer18221266.21UniProt (P46781)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS4
17L40S ribosomal protein S18polymer13716170.81UniProt (P62269)
Pfam (PF00416)
In PDB		Homo sapiens (Human)Ke-3,Ke3,Small ribosomal subunit protein uS13
18NTransfer RNA (75-MER)polymer7524231.51GenBank (174924)Homo sapiens
19PEukaryotic translation initiation factor 2 subunit 1polymer26630633.31Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha
20Q40S ribosomal protein S23polymer14215757.61UniProt (P62266)
Pfam (PF00164)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS12
21R40S ribosomal protein S19polymer14115812.31Homo sapiens (Human)Small ribosomal subunit protein eS19
22SEukaryotic translation initiation factor 2 subunit 3polymer42245862.41UniProt (P41091)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF09173)
In PDB		Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX
23U40S ribosomal protein S5polymer19121525.91UniProt (P46782)
Pfam (PF00177)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS7
24V40S ribosomal protein S30polymer596741.01UniProt (P62861)
Pfam (PF04758)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS30
25W40S ribosomal protein S25polymer758526.11UniProt (P62851)
Pfam (PF03297)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS25
26X40S ribosomal protein S7polymer19021716.41UniProt (P62081)
Pfam (PF01251)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS7
27Y40S ribosomal protein S27polymer849480.21UniProt (P42677)
Pfam (PF01667)
In PDB		Homo sapiens (Human)Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27
28Z40S ribosomal protein S13polymer15017128.21UniProt (P62277)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS15
29a40S ribosomal protein S15apolymer12914734.41UniProt (P62244)
Pfam (PF00410)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS8
30b40S ribosomal protein S21polymer828896.11Homo sapiens (Human)Small ribosomal subunit protein eS21
31c40S ribosomal protein S2polymer22624814.31Homo sapiens (Human)40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5
32dEUKARYOTIC TRANSLATION INITIATION FACTOR 2 BETA SUBUNIT (eIF2-Beta)polymer172103.41Homo sapiens
33e40S ribosomal protein S17polymer12614579.01UniProt (P08708)
Pfam (PF00833)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS17
34f40S ribosomal protein SApolymer20823360.81UniProt (P08865)
Pfam (PF00318)
In PDB		Homo sapiens (Human)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2
35g40S ribosomal protein S3polymer22725158.51UniProt (P23396)
Pfam (PF07650)
Pfam (PF00189)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS3
36h40S ribosomal protein S20polymer10411765.91UniProt (P60866)
Pfam (PF00338)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS10
37i40S ribosomal protein S3apolymer21524944.41UniProt (P61247)
Pfam (PF01015)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1
38j40S ribosomal protein S14polymer13614544.71UniProt (P62263)
Pfam (PF00411)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS11
39k40S ribosomal protein S26polymer9911315.41Homo sapiens (Human)Small ribosomal subunit protein eS26
40l40S ribosomal protein S28polymer647263.41UniProt (P62857)
Pfam (PF01200)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS28
41mReceptor of activated protein C kinase 1polymer31334669.11UniProt (P63244)
Pfam (PF00400)
In PDB		Homo sapiens (Human)Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
42n40S ribosomal protein S15polymer12715151.91UniProt (P62841)
Pfam (PF00203)
In PDB		Homo sapiens (Human)RIG protein,Small ribosomal subunit protein uS19
43o40S ribosomal protein S8polymer20623902.91UniProt (P62241)
Pfam (PF01201)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS8
44pUbiquitin-40S ribosomal protein S27apolymer718358.91UniProt (P62979)
Pfam (PF01599)
In PDB		Homo sapiens (Human)Ubiquitin carboxyl extension protein 80
45q40S ribosomal protein S6polymer23727471.51UniProt (P62753)
Pfam (PF01092)
In PDB		Homo sapiens (Human)Phosphoprotein NP33,Small ribosomal subunit protein eS6
46r40S ribosomal protein S12polymer12413766.11UniProt (P25398)
Pfam (PF01248)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS12
47s40S ribosomal protein S24polymer13115189.01UniProt (P62847)
Pfam (PF01282)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS24
48t40S ribosomal protein S10polymer9811774.01UniProt (P46783)
Pfam (PF03501)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS10
49uEukaryotic translation initiation factor 4Bpolymer63672324.81UniProt (P23588)
Pfam (PF00076)
In PDB		Homo sapiens (Human)eIF-4B
50wEukaryotic translation initiation factor 3 subunit Bpolymer1121124402.31Homo sapiens (Human)eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116
51waterwater18.0415Chemie (HOH)
Sequence modifications
6: 1 - 218 (UniProt: Q9UBQ5)
PDBExternal DatabaseDetails
Thr 166Ser 166conflict
Met 172Val 172conflict
7: 1 - 564 (UniProt: Q9Y262)
PDBExternal DatabaseDetails
Val 13Ala 13conflict
Arg 53Lys 53conflict
Thr 117Ala 117conflict
Ala 151Glu 151conflict
Ser 430Asn 430conflict
I: 1 - 263 (UniProt: P62701)
PDBExternal DatabaseDetails
Ser 25Gly 25conflict
Lys 51Arg 51conflict
Ala 78Thr 78conflict
Met 156Val 156conflict
V: 75 - 133 (UniProt: P62861)
PDBExternal DatabaseDetails
Val 83Ala 9conflict
Leu 91Pro 17conflict
Arg 102Lys 28conflict
g: 1 - 227 (UniProt: P23396)
PDBExternal DatabaseDetails
Ser 195Thr 195conflict
i: 19 - 233 (UniProt: P61247)
PDBExternal DatabaseDetails
His 136Arg 136conflict
Cys 146Arg 146conflict
n: 4 - 130 (UniProt: P62841)
PDBExternal DatabaseDetails
Ser 46Asn 46conflict
o: 2 - 207 (UniProt: P62241)
PDBExternal DatabaseDetails
Gly 47Arg 47conflict
s: 3 - 133 (UniProt: P62847)
PDBExternal DatabaseDetails
Gln 41Arg 41conflict
u: -94 - 516 (UniProt: P23588)
PDBExternal DatabaseDetails
Met -119-initiating methionine
Ser -118-expression tag
Tyr -117-expression tag
Tyr -116-expression tag
His -115-expression tag
His -114-expression tag
His -113-expression tag
His -112-expression tag
His -111-expression tag
His -110-expression tag
Asp -109-expression tag
Tyr -108-expression tag
Asp -107-expression tag
Ile -106-expression tag
Pro -105-expression tag
Thr -104-expression tag
Thr -103-expression tag
Glu -102-expression tag
Asn -101-expression tag
Leu -100-expression tag
Tyr -99-expression tag
Pro -98-expression tag
Gln -97-expression tag
Gly -96-expression tag
Ala -95-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains50
Total formula weight2006440.2
All*Total formula weight2006440.2
*Water molecules are not included.

223166

PDB entries from 2024-07-31

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