6FAW
Crystal structure of C-terminal modified Tau peptide-hybrid 4.2c-I with 14-3-3sigma
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 2 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (B) | ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY | polymer | 8 | 833.8 | 1 | UniProt (by SIFTS) (P10636) | Homo sapiens | |
| 3 | D (D) | THR-PRO-SEP-LEU-PRO-GLY | polymer | 6 | 650.6 | 1 | UniProt (by SIFTS) (P10636) | Homo sapiens | |
| 4 | E, J (A, C) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | G, H (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | I, K (B, D) | (2~{R})-2-[(~{R})-[2-(2-methoxyethoxy)phenyl]-phenyl-methyl]pyrrolidine | non-polymer | 311.4 | 2 | Chemie (D3K) | |||
| 8 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 701 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 54570.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 764.0 | |
| All* | Total formula weight | 55334.3 |
