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6FA4

Antibody derived (Abd-7) small molecule binding to KRAS.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)
GTPase KRaspolymer17319701.21UniProt (P01116)
Pfam (PF00071)
Homo sapiens (Human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2B, C, D, E, F
(A, C, D, E, F)
GTPase KRaspolymer17319685.25UniProt (P01116)
Pfam (PF00071)
Homo sapiens (Human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
3G, J, N, Q, S...
(B, A, C, D, E...)
MAGNESIUM IONnon-polymer24.36Chemie (MG)
4H, K, O, P, T...
(B, A, C, D, E...)
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERnon-polymer522.26Chemie (GNP)
5I, L, M, R, W
(B, A, D, F)
6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-aminenon-polymer391.55Chemie (D1W)
6AA, BA, CA, X, Y...
(D, E, F, B, A...)
waterwater18.0136Chemie (HOH)
Sequence modifications
B: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Ala -3-expression tag
Phe -2-expression tag
Gln -1-expression tag
Gly 0-expression tag
His 61Gln 61engineered mutation
A, C, D, E, F: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Ala -3-expression tag
Phe -2-expression tag
Gln -1-expression tag
Gly 0-expression tag
His 61Gln 61engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight118127.3
Non-Polymers*Number of molecules17
Total formula weight5236.3
All*Total formula weight123363.6
*Water molecules are not included.

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PDB entries from 2025-10-15

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