6FA3
Antibody derived (Abd-6) small molecule binding to KRAS.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, C, D, E, F | GTPase KRas | polymer | 172 | 19572.0 | 5 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | A | GTPase KRas | polymer | 172 | 19556.0 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
3 | B, A, C, D, E... | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
4 | B, A, C, D, E... | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 6 | Chemie (GNP) | |||
5 | B, A, C, F | ~{N}-[[(3~{R})-5-[5-[[3-[(dimethylamino)methyl]phenyl]amino]-6-methoxy-pyridin-2-yl]-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]oxane-4-carboxamide | non-polymer | 532.6 | 4 | Chemie (D1Z) | |||
6 | F | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
7 | water | water | 18.0 | 361 | Chemie (HOH) |
Sequence modifications
B, C, D, E, F: 1 - 168 (UniProt: P01116)
A: 1 - 168 (UniProt: P01116)
PDB | External Database | Details |
---|---|---|
Ala -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
His 61 | Gln 61 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
His 61 | Gln 61 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 117416.2 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 5487.7 | |
All* | Total formula weight | 122903.8 |