6F38
Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ARP1 actin related protein 1 homolog A | polymer | 376 | 42670.7 | 8 | UniProt (F2Z5G5) Pfam (PF00022) | Sus scrofa (Pig) | |
| 2 | H (H) | Actin, cytoplasmic 1 | polymer | 375 | 41782.7 | 1 | UniProt (Q6QAQ1) Pfam (PF00022) | Sus scrofa (Pig) | Beta-actin |
| 3 | J (J) | Actin related protein 10 homolog | polymer | 390 | 43203.3 | 1 | UniProt (I3LHK5) Pfam (PF00022) | Sus scrofa (Pig) | |
| 4 | K (K) | Capping protein (Actin filament) muscle Z-line, alpha 1 | polymer | 286 | 33059.8 | 1 | UniProt (A0PFK5) Pfam (PF01267) | Sus scrofa (Pig) | F-actin capping protein alpha 1 subunit,F-actin capping protein subunit alpha 1 |
| 5 | L (L) | F-actin capping protein beta subunit | polymer | 272 | 30669.8 | 1 | UniProt (A9XFX6) Pfam (PF01115) UniProt (by SIFTS) (A0PFK7) | Sus scrofa (Pig) | F-actin-capping protein subunit beta,F-actin-capping protein subunit beta isoform 1 |
| 6 | M (M) | Dynactin Subunit 2 | polymer | 587 | 49974.7 | 1 | Sus scrofa (Pig) | ||
| 7 | N (N) | Dynactin Subunit 2 | polymer | 616 | 52442.8 | 1 | Sus scrofa (Pig) | ||
| 8 | O, P (O, P) | Dynactin Subunit 3 | polymer | 65 | 5549.8 | 2 | Sus scrofa (Pig) | ||
| 9 | Q, R (Q, R) | Dynactin Subunit 2 | polymer | 87 | 7422.1 | 2 | Sus scrofa (Pig) | ||
| 10 | S (U) | Dynactin 6 | polymer | 190 | 20703.9 | 1 | UniProt (D0G6S1) | Sus scrofa (Pig) | |
| 11 | T (V) | Dynactin subunit 5 | polymer | 182 | 20150.5 | 1 | UniProt (A0A286ZK88) Pfam (PF21711) | Sus scrofa (Pig) | |
| 12 | RA, U (X, x) | HOOK3 | polymer | 223 | 18996.3 | 2 | Homo sapiens (Human) | ||
| 13 | V (Y) | Dynactin Subunit 4 | polymer | 264 | 22485.6 | 1 | Sus scrofa (Pig) | ||
| 14 | W (Z) | Dynactin Subunit 1 | polymer | 52 | 4443.5 | 1 | Sus scrofa (Pig) | ||
| 15 | X (a) | Dynactin subunit 2 | polymer | 68 | 7578.2 | 1 | UniProt (F1SKF9) UniProt (by SIFTS) (A0A5G2QD80) | Sus scrofa (Pig) | |
| 16 | Y (b) | Dynactin subunit 2 | polymer | 90 | 10147.0 | 1 | UniProt (F1SKF9) UniProt (by SIFTS) (A0A5G2QD80) | Sus scrofa (Pig) | |
| 17 | Z (c) | Dynactin subunit 2 | polymer | 50 | 5551.9 | 1 | UniProt (F1SL58) | Sus scrofa (Pig) | |
| 18 | AA (d) | Dynactin subunit 2 | polymer | 29 | 3239.4 | 1 | UniProt (F1SL58) UniProt (by SIFTS) (A0A5G2QD80) | Sus scrofa (Pig) | |
| 19 | BA, CA, JA, KA (e, f, m, n) | Cytoplasmic dynein 1 heavy chain 1 | polymer | 1455 | 168318.8 | 4 | UniProt (Q14204) Pfam (PF08385) Pfam (PF08393) | Homo sapiens (Human) | Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic |
| 20 | DA, EA, LA, MA (g, h, o, p) | Cytoplasmic dynein 1 intermediate chain 2 | polymer | 612 | 68442.1 | 4 | UniProt (Q13409) Pfam (PF00400) Pfam (PF11540) | Homo sapiens (Human) | Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2 |
| 21 | FA, GA, NA, OA (i, j, q, r) | Cytoplasmic dynein 1 light intermediate chain 2 | polymer | 492 | 54173.2 | 4 | UniProt (O43237) Pfam (PF05783) | Homo sapiens (Human) | Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55 |
| 22 | HA, IA, PA, QA (k, l, s, t) | Dynein light chain roadblock-type 1 | polymer | 96 | 10934.6 | 4 | UniProt (Q9NP97) Pfam (PF03259) | Homo sapiens (Human) | Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1 |
| 23 | SA (z) | Dynactin Subunit 1 | polymer | 53 | 4528.6 | 1 | Sus scrofa (Pig) | ||
| 24 | BB, CB, TA, UA, VA... (I, J, A, B, C...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 9 | Chemie (ADP) | |||
| 25 | AB (H) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
g, h, o, p: 1 - 612 (UniProt: Q13409)
| PDB | External Database | Details |
|---|---|---|
| Ser 484 | Thr 484 | conflict |
| Gly 499 | Asp 499 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 1962738.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 4352.0 | |
| All* | Total formula weight | 1967090.4 |
