6F30
Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) in complex with UDPGlcNAc
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | polymer | 749 | 85370.3 | 2 | UniProt (P97675) Pfam (PF01663) In PDB | Rattus norvegicus (Rat) | E-NPP 3,B10,Phosphodiesterase I beta,PD-Ibeta,Phosphodiesterase I/nucleotide pyrophosphatase 3,RB13-6 antigen |
2 | C, D, E, F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
3 | H | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | A, B | URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | non-polymer | 607.4 | 2 | Chemie (UD1) | |||
5 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
6 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
7 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
8 | water | water | 18.0 | 610 | Chemie (HOH) |
Sequence modifications
A, B: 140 - 875 (UniProt: P97675)
PDB | External Database | Details |
---|---|---|
Ala 136 | - | expression tag |
Glu 137 | - | expression tag |
Thr 138 | - | expression tag |
Gly 139 | - | expression tag |
Val 201 | Met 201 | variant |
Ala 206 | Thr 206 | engineered mutation |
Glu 585 | Gln 585 | conflict |
Asn 596 | Ser 596 | variant |
Arg 597 | Gly 597 | variant |
Gly 876 | - | expression tag |
Thr 877 | - | expression tag |
Lys 878 | - | expression tag |
His 879 | - | expression tag |
His 880 | - | expression tag |
His 881 | - | expression tag |
His 882 | - | expression tag |
His 883 | - | expression tag |
His 884 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 170740.7 | |
Branched | Number of molecules | 6 |
Total formula weight | 2708.5 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2662.5 | |
All* | Total formula weight | 176111.8 |