6EZO
Eukaryotic initiation factor EIF2B in complex with ISRIB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit alpha |
| 2 | C, D (C, D) | Translation initiation factor eIF-2B subunit beta | polymer | 373 | 41758.2 | 2 | UniProt (P49770) Pfam (PF01008) | Homo sapiens (Human) | S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta |
| 3 | E, F (E, F) | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit gamma |
| 4 | G, H (G, H) | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit delta |
| 5 | I, J (I, J) | Human eukaryotic initiation factor EIF2B epsilon subunits | polymer | 721 | 80466.6 | 2 | UniProt (Q13144) Pfam (PF02020) | Homo Sapiens (human) | |
| 6 | K (D) | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide | non-polymer | 451.3 | 1 | Chemie (C7B) |
Sequence modifications
C, D: 5 - 351 (UniProt: P49770)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| Pro -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Lys -15 | - | expression tag |
| Asp -14 | - | expression tag |
| His -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Tyr -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Asp -7 | - | expression tag |
| His -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Lys 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 527846.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 451.3 | |
| All* | Total formula weight | 528298.1 |
