6EZO
Eukaryotic initiation factor EIF2B in complex with ISRIB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) In PDB | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit alpha |
2 | C, D | Translation initiation factor eIF-2B subunit beta | polymer | 373 | 41758.2 | 2 | UniProt (P49770) Pfam (PF01008) In PDB | Homo sapiens (Human) | S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta |
3 | E, F | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) In PDB | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit gamma |
4 | G, H | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) In PDB | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit delta |
5 | I, J | Human eukaryotic initiation factor EIF2B epsilon subunits | polymer | 721 | 80466.6 | 2 | UniProt (Q13144) Pfam (PF02020) In PDB | Homo Sapiens (human) | |
6 | D | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide | non-polymer | 451.3 | 1 | Chemie (C7B) |
Sequence modifications
C, D: 5 - 351 (UniProt: P49770)
PDB | External Database | Details |
---|---|---|
Met -21 | - | initiating methionine |
Pro -20 | - | expression tag |
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
Asp -17 | - | expression tag |
Tyr -16 | - | expression tag |
Lys -15 | - | expression tag |
Asp -14 | - | expression tag |
His -13 | - | expression tag |
Asp -12 | - | expression tag |
Gly -11 | - | expression tag |
Asp -10 | - | expression tag |
Tyr -9 | - | expression tag |
Lys -8 | - | expression tag |
Asp -7 | - | expression tag |
His -6 | - | expression tag |
Asp -5 | - | expression tag |
Ile -4 | - | expression tag |
Asp -3 | - | expression tag |
Tyr -2 | - | expression tag |
Lys -1 | - | expression tag |
Asp 0 | - | expression tag |
Asp 1 | - | expression tag |
Asp 2 | - | expression tag |
Asp 3 | - | expression tag |
Lys 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 527846.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 451.3 | |
All* | Total formula weight | 528298.1 |