6EVP

Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Glu-Gly-Pro-Pro-Gly.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Prolyl 4-hydroxylase subunit alpha-2	polymer	102	11920.3	1	UniProt (O15460) In PDB	Homo sapiens (Human)	4-PH alpha-2,Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
2	C	PRO-PRO-GLY-PRO-GLU-GLY-PRO-PRO-GLY	polymer	9	803.9	1		synthetic construct
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	A	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
5		water	water		18.0	49	Chemie (HOH)

Sequence modifications

A: 144 - 238 (UniProt: O15460)

PDB	External Database	Details
Met 137	-	initiating methionine
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	12724.1
Non-Polymers*	Number of molecules	4
	Total formula weight	330.5
All*	Total formula weight	13054.6

*Water molecules are not included.