6EQS
Human Sirt5 in complex with stalled peptidylimidate intermediate of inhibitory compound 29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 275 | 29913.1 | 4 | UniProt (Q9NXA8) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 5,SIR2-like protein 5 |
| 2 | E, FA, P, Z (A, D, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | AA, F, GA, Q (C, A, D, B) | 3-[[(~{Z})-~{C}-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]sulfanyl-~{N}-[(5~{S})-6-[[(2~{S})-3-(1~{H}-indol-3-yl)-1-oxidanylidene-1-(propan-2-ylamino)propan-2-yl]amino]-6-oxidanylidene-5-(phenylmethoxycarbonylamino)hexyl]carbonimidoyl]amino]propanoic acid | non-polymer | 1180.1 | 4 | Chemie (BV8) | |||
| 4 | BA, CA, DA, G, H... (C, A, D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 5 | EA, JA, KA, L, M... (C, D, A, B) | 1,3-BUTANEDIOL | non-polymer | 90.1 | 8 | Chemie (BU2) | |||
| 6 | N, O (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 7 | LA, MA, NA, OA (A, B, C, D) | water | water | 18.0 | 1086 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 302 (UniProt: Q9NXA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ile 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Pro 31 | - | expression tag |
| Phe 32 | - | expression tag |
| Thr 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119652.3 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 6790.2 | |
| All* | Total formula weight | 126442.5 |
