6EPM
Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | R | GTPase KRas | polymer | 170 | 19386.8 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | S | Son of sevenless homolog 1 | polymer | 487 | 57103.3 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (Human) | SOS-1 |
| 3 | R | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | S | (1-phenyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)methanamine | non-polymer | 213.3 | 1 | Chemie (BQ5) | |||
| 5 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
R: 1 - 169 (UniProt: P01116)
S: 563 - 1049 (UniProt: Q07889)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Glu 126 | Asp 126 | engineered mutation |
| Ser 127 | Thr 127 | engineered mutation |
| Arg 128 | Lys 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 563 | Lys 563 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76490.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 305.4 | |
| All* | Total formula weight | 76795.5 |
