6EP9
Crystal structure of BTK kinase domain complexed with N-[2-methyl-3-[4-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]-5-oxo-pyrazin-2-yl]phenyl]-4-(1-piperidyl)benzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 283 | 32521.1 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | B (A) | N-[2-methyl-3-[4-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]-5-oxo-pyrazin-2-yl]phenyl]-4-(1-piperidyl)benzamide | non-polymer | 619.8 | 1 | Chemie (BNB) | |||
| 3 | C (A) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A: 378 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 377 | - | expression tag |
| Ala 489 | Met 489 | engineered mutation |
| Ala 492 | Arg 492 | engineered mutation |
| Ala 624 | Glu 624 | engineered mutation |
| Ala 625 | Lys 625 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32521.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 619.8 | |
| All* | Total formula weight | 33140.9 |
