6EO9

Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor

Replaces:  4NZE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Prothrombin	polymer	259	29780.2	1	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (Human)	Coagulation factor II
2	L	Prothrombin	polymer	36	4096.5	1	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (Human)	Coagulation factor II
3	I	Hirudin variant-2	polymer	12	1534.6	1	UniProt (P09945) In PDB	Hirudo medicinalis (Medicinal leech)
4	H	DIMETHYL SULFOXIDE	non-polymer		78.1	6	Chemie (DMS)
5	H	N-(2-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methoxy}-6-{3-[(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)oxy]propoxy}phenyl)-1-(propan-2-yl)piperidine-4-carboxamide	non-polymer		864.4	1	Chemie (2OJ)
6		water	water		18.0	118	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	35411.3
Non-Polymers*	Number of molecules	7
	Total formula weight	1333.2
All*	Total formula weight	36744.5

*Water molecules are not included.