6ELA
Crystal structure of MMP12 in complex with inhibitor BE4.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Macrophage metalloelastase | polymer | 159 | 17557.6 | 4 | UniProt (P39900) Pfam (PF00413) | Homo sapiens (Human) | MME,Macrophage elastase,hME,Matrix metalloproteinase-12,MMP-12 |
| 2 | AA, BA, E, F, L... (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | CA, DA, EA, G, H... (D, A, B, C) | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
| 4 | FA, J, Q, Y (D, A, B, C) | (2~{S})-2-[2-[4-(4-methoxyphenyl)phenyl]sulfanylphenyl]pentanedioic acid | non-polymer | 422.5 | 4 | Chemie (B9Z) | |||
| 5 | GA, HA, K, R, Z (D, A, B, C) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 5 | Chemie (DIO) | |||
| 6 | X (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | IA, JA, KA, LA (A, B, C, D) | water | water | 18.0 | 863 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 106 - 263 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Met 105 | - | initiating methionine |
| Asp 171 | Phe 171 | engineered mutation |
| Ala 241 | Lys 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70230.3 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 3196.8 | |
| All* | Total formula weight | 73427.0 |
