6EIV
DYRK1A in complex with JWD-065
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 368 | 42654.0 | 4 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
| 2 | E, F, G, H (A, B, C, D) | ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide | non-polymer | 464.6 | 4 | Chemie (B6Q) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 126 - 490 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| Ala 124 | - | expression tag |
| Ser 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170616.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1858.3 | |
| All* | Total formula weight | 172474.3 |
