6EHP

The crystal structure of the human LAMTOR complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ragulator complex protein LAMTOR3	polymer	127	13904.0	1	UniProt (Q9UHA4) Pfam (PF08923) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1
2	B	Ragulator complex protein LAMTOR2	polymer	126	13574.5	1	UniProt (Q9Y2Q5) Pfam (PF03259) In PDB	Homo sapiens (Human)	Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3
3	C	Ragulator complex protein LAMTOR5	polymer	91	9622.9	1	UniProt (O43504) Pfam (PF16672) In PDB	Homo sapiens (Human)	Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
4	D	Ragulator complex protein LAMTOR4	polymer	99	10753.2	1	UniProt (Q0VGL1) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
5	E	Ragulator complex protein LAMTOR1	polymer	145	15828.8	1	UniProt (Q6IAA8) Pfam (PF15454) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho
6	D	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7		water	water		18.0	71	Chemie (HOH)

Sequence modifications

A: 1 - 124 (UniProt: Q9UHA4)

PDB	External Database	Details
Gly -2	-	expression tag
Ala -1	-	expression tag
His 0	-	expression tag

B: 2 - 125 (UniProt: Q9Y2Q5)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 1	-	expression tag

E: 21 - 161 (UniProt: Q6IAA8)

PDB	External Database	Details
Ser 17	-	expression tag
Leu 18	-	expression tag
Met 19	-	expression tag
Thr 20	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	63683.4
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	63718.9

*Water molecules are not included.