6EGE
Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (D, A) | Interleukin-1 receptor-associated kinase 4 | polymer | 302 | 33716.3 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | C, D (D, A) | N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide | non-polymer | 379.4 | 2 | Chemie (DL1) | |||
| 3 | E, F (D, A) | water | water | 18.0 | 672 | Chemie (HOH) |
Sequence modifications
D, A: 164 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 159 | - | expression tag |
| Ala 160 | - | expression tag |
| Met 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Ser 163 | - | expression tag |
| Asn 311 | Asp 311 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67432.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 758.8 | |
| All* | Total formula weight | 68191.5 |
