6EGD
Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A | Interleukin-1 receptor-associated kinase 4 | polymer | 302 | 33716.3 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
2 | D, A | N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | non-polymer | 396.5 | 2 | Chemie (J87) | |||
3 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
D, A: 164 - 460 (UniProt: Q9NWZ3)
PDB | External Database | Details |
---|---|---|
Gly 159 | - | expression tag |
Ala 160 | - | expression tag |
Met 161 | - | expression tag |
Gly 162 | - | expression tag |
Ser 163 | - | expression tag |
Asn 311 | Asp 311 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67432.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 792.9 | |
All* | Total formula weight | 68225.6 |