6EG9
IRAK4 in complex with Ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-1 receptor-associated kinase 4 | polymer | 312 | 34821.5 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | C, F (A, B) | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 2 | Chemie (0LI) | |||
| 3 | D, G (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, H, I, J (A, B) | COBALT (II) ION | non-polymer | 58.9 | 4 | Chemie (CO) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 149 | - | expression tag |
| Ala 150 | - | expression tag |
| Met 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69642.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1493.0 | |
| All* | Total formula weight | 71135.9 |
