6EF3
Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | Proteasome subunit beta type-1 | polymer | 215 | 23573.6 | 1 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PRE3,Multicatalytic endopeptidase complex subunit PRE3,Proteasome component PRE3,Proteinase YSCE subunit PRE3 |
| 2 | B (2) | Proteasome subunit beta type-2 | polymer | 261 | 28299.9 | 1 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PUP1,Multicatalytic endopeptidase complex subunit PUP1,Proteasome component PUP1,Proteinase YSCE subunit PUP1 |
| 3 | C (3) | Proteasome subunit beta type-3 | polymer | 205 | 22627.8 | 1 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PUP3,Multicatalytic endopeptidase complex subunit PUP3,Proteasome component PUP3 |
| 4 | D (4) | Proteasome subunit beta type-4 | polymer | 198 | 22545.7 | 1 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit C11,Multicatalytic endopeptidase complex subunit C11,Proteasome component C11,Proteinase YSCE subunit 11 |
| 5 | E (5) | Proteasome subunit beta type-5 | polymer | 287 | 31670.5 | 1 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PRE2,Multicatalytic endopeptidase complex subunit PRE2,Proteasome component PRE2,Proteinase YSCE subunit PRE2 |
| 6 | F (6) | Proteasome subunit beta type-6 | polymer | 241 | 26905.1 | 1 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Multicatalytic endopeptidase complex subunit C5,Proteasome component C5 |
| 7 | G (7) | Proteasome subunit beta type-7 | polymer | 266 | 29471.3 | 1 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PRE4,Multicatalytic endopeptidase complex subunit PRE4,Proteasome component PRE4,Proteinase YSCE subunit PRE4 |
| 8 | H (A) | Proteasome subunit alpha type-1 | polymer | 252 | 28033.8 | 1 | UniProt (P21243) Pfam (PF00227) Pfam (PF10584) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit C7-alpha,Multicatalytic endopeptidase complex C7,Proteasome component C7-alpha,Proteasome component Y8,Proteinase YSCE subunit 7,SCL1 suppressor protein |
| 9 | I (B) | Proteasome subunit alpha type-2 | polymer | 250 | 27191.8 | 1 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit Y7,Multicatalytic endopeptidase complex subunit Y7,Proteasome component Y7,Proteinase YSCE subunit 7 |
| 10 | J (C) | Proteasome subunit alpha type-3 | polymer | 258 | 28748.2 | 1 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit Y13,Multicatalytic endopeptidase complex subunit Y13,Proteasome component Y13,Proteinase YSCE subunit 13 |
| 11 | K (D) | Proteasome subunit alpha type-4 | polymer | 254 | 28478.1 | 1 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PRE6,Multicatalytic endopeptidase complex subunit PRE6,Proteasome component PRE6,Proteinase YSCE subunit PRE6 |
| 12 | L (E) | Proteasome subunit alpha type-5 | polymer | 260 | 28649.1 | 1 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PUP2,Multicatalytic endopeptidase complex subunit PUP2,Proteasome component PUP2,Proteinase YSCE subunit PUP2 |
| 13 | M (F) | Proteasome subunit alpha type-6 | polymer | 234 | 25634.0 | 1 | UniProt (P40302) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit PRE5,Multicatalytic endopeptidase complex subunit PRE5,Proteasome component PRE5,Proteinase YSCE subunit PRE5 |
| 14 | N (G) | Probable proteasome subunit alpha type-7 | polymer | 288 | 31575.1 | 1 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae S288c (Baker's yeast) | Macropain subunit C1,Multicatalytic endopeptidase complex subunit C1,Proteasome component C1,Proteinase YSCE subunit 1 |
| 15 | O (H) | 26S proteasome regulatory subunit 7 homolog | polymer | 467 | 52054.9 | 1 | UniProt (P33299) Pfam (PF21236) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae S288c (Baker's yeast) | Protein CIM5,Tat-binding homolog 3 |
| 16 | P (I) | 26S proteasome regulatory subunit 4 homolog | polymer | 437 | 48898.2 | 1 | UniProt (P40327) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae S288c (Baker's yeast) | Tat-binding homolog 5 |
| 17 | Q (J) | 26S proteasome regulatory subunit 8 homolog | polymer | 405 | 45342.7 | 1 | UniProt (Q01939) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae S288c (Baker's yeast) | Protein CIM3,Protein SUG1,Tat-binding protein TBY1 |
| 18 | R (K) | 26S proteasome regulatory subunit 6B homolog | polymer | 428 | 47953.7 | 1 | UniProt (P33298) Pfam (PF16450) Pfam (PF00004) | Saccharomyces cerevisiae S288c (Baker's yeast) | Protein YNT1,Tat-binding homolog 2 |
| 19 | S (L) | 26S proteasome subunit RPT4 | polymer | 437 | 49480.1 | 1 | UniProt (P53549) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae S288c (Baker's yeast) | 26S protease subunit SUG2,Proteasomal cap subunit |
| 20 | T (M) | 26S proteasome regulatory subunit 6A | polymer | 434 | 48315.7 | 1 | UniProt (P33297) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae S288c (Baker's yeast) | Tat-binding protein homolog 1,TBP-1 |
| 21 | U (n) | Proteasome subunit beta type-7 | polymer | 15 | 1789.0 | 1 | UniProt (by SIFTS) (P30657) | Saccharomyces cerevisiae S288c (Baker's yeast) | |
| 22 | V (r) | Ubiquitin carboxyl-terminal hydrolase RPN11 | polymer | 306 | 34442.3 | 1 | UniProt (P43588) Pfam (PF01398) | Saccharomyces cerevisiae S288c (Baker's yeast) | 26S proteasome regulatory subunit RPN11,Protein MPR1 |
| 23 | W (s) | Model substrate polypeptide | polymer | 38 | 4068.4 | 1 | UniProt (by SIFTS) (P07818) | Homo sapiens (Human) | |
| 24 | X (u) | Ubiquitin-60S ribosomal protein L40 | polymer | 128 | 14583.1 | 1 | UniProt (P0CH08) Pfam (PF00240) Pfam (PF01020) | Saccharomyces cerevisiae S288c (Baker's yeast) | |
| 25 | AA, DA, Y, Z (J, M, H, I) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 26 | BA, CA (K, L) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 730332.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2883.1 | |
| All* | Total formula weight | 733215.3 |
