6EE4
X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | M1 family aminopeptidase | polymer | 889 | 103631.6 | 1 | UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB | Plasmodium falciparum (isolate FcB1 / Columbia) | Pfa-M1 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | (2R)-2-[(cyclopropylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide | non-polymer | 378.3 | 1 | Chemie (J4S) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
5 | A | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
6 | A | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
7 | water | water | 18.0 | 1499 | Chemie (HOH) |
Sequence modifications
A: 196 - 1084 (UniProt: O96935)
PDB | External Database | Details |
---|---|---|
Gln 213 | Asn 213 | engineered mutation |
Gln 223 | Asn 223 | engineered mutation |
Pro 378 | His 378 | engineered mutation |
Gln 501 | Asn 501 | engineered mutation |
Gln 745 | Asn 745 | engineered mutation |
Gln 795 | Asn 795 | engineered mutation |
Gln 1069 | Asn 1069 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 103631.6 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 1310.7 | |
All* | Total formula weight | 104942.3 |