6EDR
Crystal Structure of Human CD38 in Complex with 4'-Thioribose NAD+
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | polymer | 257 | 29763.7 | 2 | UniProt (P28907) Pfam (PF02267) In PDB | Homo sapiens (Human) | 2'-phospho-ADP-ribosyl cyclase,2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase,2'-phospho-cyclic-ADP-ribose transferase,ADP-ribosyl cyclase 1,ADPRC 1,Cyclic ADP-ribose hydrolase 1,cADPr hydrolase 1,T10 |
2 | A, B | [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)thiolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | non-polymer | 680.5 | 2 | Chemie (ZNA) | |||
3 | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 300 (UniProt: P28907)
PDB | External Database | Details |
---|---|---|
Ser 44 | - | expression tag |
Asp 100 | Asn 100 | engineered mutation |
Ala 164 | Asn 164 | engineered mutation |
Asp 209 | Asn 209 | engineered mutation |
Asp 219 | Asn 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 59527.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1361.0 | |
All* | Total formula weight | 60888.5 |