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6EDL

hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
ALK tyrosine kinase receptorpolymer32236045.41UniProt (Q9UM73)
Pfam (PF07714)
Homo sapiens (Human)Anaplastic lymphoma kinase
2B
(A)
N-[(1S)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-aminenon-polymer354.41Chemie (J4M)
3C
(A)
waterwater18.014Chemie (HOH)
Sequence modifications
A: 1090 - 1406 (UniProt: Q9UM73)
PDBExternal DatabaseDetails
Gly 1085-expression tag
Ala 1086-expression tag
Met 1087-expression tag
Gly 1088-expression tag
Ser 1089-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36045.4
Non-Polymers*Number of molecules1
Total formula weight354.4
All*Total formula weight36399.7
*Water molecules are not included.

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PDB entries from 2024-10-30

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