6EDL
hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | ALK tyrosine kinase receptor | polymer | 322 | 36045.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (Human) | Anaplastic lymphoma kinase |
2 | B (A) | N-[(1S)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine | non-polymer | 354.4 | 1 | Chemie (J4M) | |||
3 | C (A) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A: 1090 - 1406 (UniProt: Q9UM73)
PDB | External Database | Details |
---|---|---|
Gly 1085 | - | expression tag |
Ala 1086 | - | expression tag |
Met 1087 | - | expression tag |
Gly 1088 | - | expression tag |
Ser 1089 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36045.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 354.4 | |
All* | Total formula weight | 36399.7 |