6EAH
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT K394R-S398L STABILIZED IN THE PREFUSION STATE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Fusion glycoprotein F0 | polymer | 568 | 63272.4 | 3 | UniProt (W8RJF9) Pfam (PF00523) UniProt (by SIFTS) (P03420) | Human respiratory syncytial virus | |
| 2 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | E, F, G, H, I... (A, B, C) | SULFATE ION | non-polymer | 96.1 | 20 | Chemie (SO4) | |||
| 4 | N (A) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) |
Sequence modifications
A, B, C: 1 - 513 (UniProt: W8RJF9)
| PDB | External Database | Details |
|---|---|---|
| Glu 66 | Lys 66 | conflict |
| Cys 155 | Ser 155 | engineered mutation |
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Cys 290 | Ser 290 | engineered mutation |
| Arg 394 | Lys 394 | engineered mutation |
| Leu 398 | Ser 398 | engineered mutation |
| Ser 514 | - | expression tag |
| Ala 515 | - | expression tag |
| Ile 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Gly 518 | - | expression tag |
| Tyr 519 | - | expression tag |
| Ile 520 | - | expression tag |
| Pro 521 | - | expression tag |
| Glu 522 | - | expression tag |
| Ala 523 | - | expression tag |
| Pro 524 | - | expression tag |
| Arg 525 | - | expression tag |
| Asp 526 | - | expression tag |
| Gly 527 | - | expression tag |
| Gln 528 | - | expression tag |
| Ala 529 | - | expression tag |
| Tyr 530 | - | expression tag |
| Val 531 | - | expression tag |
| Arg 532 | - | expression tag |
| Lys 533 | - | expression tag |
| Asp 534 | - | expression tag |
| Gly 535 | - | expression tag |
| Glu 536 | - | expression tag |
| Trp 537 | - | expression tag |
| Val 538 | - | expression tag |
| Leu 539 | - | expression tag |
| Leu 540 | - | expression tag |
| Ser 541 | - | expression tag |
| Thr 542 | - | expression tag |
| Phe 543 | - | expression tag |
| Leu 544 | - | expression tag |
| Gly 545 | - | expression tag |
| Gly 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Val 548 | - | expression tag |
| Pro 549 | - | expression tag |
| Arg 550 | - | expression tag |
| Gly 551 | - | expression tag |
| Ser 552 | - | expression tag |
| His 553 | - | expression tag |
| His 554 | - | expression tag |
| His 555 | - | expression tag |
| His 556 | - | expression tag |
| His 557 | - | expression tag |
| His 558 | - | expression tag |
| Ser 559 | - | expression tag |
| Ala 560 | - | expression tag |
| Trp 561 | - | expression tag |
| Ser 562 | - | expression tag |
| His 563 | - | expression tag |
| Pro 564 | - | expression tag |
| Gln 565 | - | expression tag |
| Phe 566 | - | expression tag |
| Glu 567 | - | expression tag |
| Lys 568 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 189817.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2128.6 | |
| All* | Total formula weight | 192516.4 |
