6EA4
ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Endoplasmic reticulum aminopeptidase 2 | polymer | 911 | 105116.0 | 2 | UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (human) | Leukocyte-derived arginine aminopeptidase,L-RAP |
| 2 | C, D, G (C, D, G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 3 | E, F, I (E, F, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 4 | H (H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | J, V (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | Leukocyte-derived arginine aminopeptidase,L-RAP | ||
| 6 | K, W (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 7 | L, X (A, B) | 4-methoxy-3-{[2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl]sulfamoyl}benzoic acid | non-polymer | 458.5 | 2 | Chemie (J2G) | |||
| 8 | EA, M, R, Y (B, A) | LYSINE | non-polymer | 147.2 | 4 | Chemie (LYS) | |||
| 9 | AA, BA, N, O, P... (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 10 | CA, S (B, A) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 11 | T (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 12 | DA, U (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 13 | FA, GA (A, B) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 53 - 960 (UniProt: Q6P179)
| PDB | External Database | Details |
|---|---|---|
| Asn 392 | Lys 392 | variant |
| Arg 961 | - | expression tag |
| His 962 | - | expression tag |
| His 963 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 210232.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4592.2 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3987.9 | |
| All* | Total formula weight | 218812.1 |
