6E7S
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Glutamate receptor ionotropic, NMDA 1 | polymer | 385 | 43162.3 | 2 | UniProt (A0A1L8F5J9) Pfam (PF01094) | Xenopus laevis (African clawed frog) | GluN1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D (B, D) | Glutamate receptor ionotropic, NMDA 2B | polymer | 363 | 41280.8 | 2 | UniProt (Q00960) Pfam (PF01094) | Rattus norvegicus (Rat) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B |
| 3 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G, H, L, M, R... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 6 | I, T (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | J, K, O, P, Q... (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 8 | N, X (B, D) | N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](ethyl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide | non-polymer | 461.4 | 2 | Chemie (HZ4) | |||
| 9 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A, C: 23 - 407 (UniProt: A0A1L8F5J9)
B, D: 32 - 394 (UniProt: Q00960)
| PDB | External Database | Details |
|---|---|---|
| Gln 61 | Asn 61 | engineered mutation |
| Gln 371 | Asn 371 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 348 | Asn 348 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168886.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1335.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 3022.1 | |
| All* | Total formula weight | 173243.5 |
