6E4U
Structure of AMPK bound to activator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 503 | 57779.1 | 1 | UniProt (P54645) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) | Rattus norvegicus (Rat) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1,AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
| 2 | B (B) | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 204 | 23097.2 | 1 | UniProt (P80386) Pfam (PF16561) Pfam (PF04739) | Rattus norvegicus (Rat) | AMPKb,5'-AMP-activated protein kinase 40 kDa subunit |
| 3 | C (C) | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) | Rattus norvegicus (Rat) | AMPKg |
| 4 | D (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 5 | E (A) | 1-O-{6-chloro-5-[6-(dimethylamino)-2-methoxypyridin-3-yl]-1H-indole-3-carbonyl}-beta-D-glucopyranuronic acid | non-polymer | 521.9 | 1 | Chemie (HU7) | |||
| 6 | F, G, H, I (A) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) PubChem (312) | |||
| 7 | J, K (C) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 8 | L (C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 9 | M (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A: 0 - 516 (UniProt: P54645)
A: 525 - 548 (UniProt: P54645)
B: 68 - 270 (UniProt: P80386)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 517 | - | linker |
| Ser 518 | - | linker |
| Gly 519 | - | linker |
| Gly 520 | - | linker |
| Pro 521 | - | linker |
| Gly 522 | - | linker |
| Gly 523 | - | linker |
| Ser 524 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118310.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2348.0 | |
| All* | Total formula weight | 120658.4 |
