6E3Y
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | P | Calcitonin gene-related peptide 1 | polymer | 38 | 3795.4 | 1 | UniProt (P06881) In PDB | Homo sapiens | Alpha-type CGRP,Calcitonin gene-related peptide I,CGRP-I |
2 | N | Nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama (llama) | ||
3 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
6 | R | Calcitonin gene-related peptide type 1 receptor | polymer | 490 | 56274.5 | 1 | UniProt (Q16602) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (Human) | CGRP type 1 receptor,Calcitonin receptor-like receptor |
7 | E | Receptor activity-modifying protein 1 | polymer | 149 | 17066.7 | 1 | UniProt (O60894) Pfam (PF04901) In PDB | Homo sapiens (Human) | Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1 |
Sequence modifications
P: 1 - 37 (UniProt: P06881)
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: 22 - 461 (UniProt: Q16602)
E: 27 - 148 (UniProt: O60894)
PDB | External Database | Details |
---|---|---|
Nh2 38 | - | amidation |
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | engineered mutation |
Ala 226 | Gly 226 | engineered mutation |
Ala 268 | Glu 268 | engineered mutation |
Lys 271 | Asn 271 | engineered mutation |
Asp 274 | Lys 274 | engineered mutation |
Lys 280 | Arg 280 | engineered mutation |
Asp 284 | Thr 284 | engineered mutation |
Thr 285 | Ile 285 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
Lys -8 | - | expression tag |
Thr -7 | - | expression tag |
Ile -6 | - | expression tag |
Ile -5 | - | expression tag |
Ala -4 | - | expression tag |
Leu -3 | - | expression tag |
Ser -2 | - | expression tag |
Tyr -1 | - | expression tag |
Ile 0 | - | expression tag |
Phe 1 | - | expression tag |
Cys 2 | - | expression tag |
Leu 3 | - | expression tag |
Val 4 | - | expression tag |
Phe 5 | - | expression tag |
Ala 6 | - | expression tag |
Asp 7 | - | expression tag |
Tyr 8 | - | expression tag |
Lys 9 | - | expression tag |
Asp 10 | - | expression tag |
Asp 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Leu 14 | - | expression tag |
Glu 15 | - | expression tag |
Val 16 | - | expression tag |
Leu 17 | - | expression tag |
Phe 18 | - | expression tag |
Gln 19 | - | expression tag |
Gly 20 | - | expression tag |
Pro 21 | - | expression tag |
Pro 462 | - | expression tag |
Ala 463 | - | expression tag |
Gly 464 | - | expression tag |
Leu 465 | - | expression tag |
Glu 466 | - | expression tag |
Val 467 | - | expression tag |
Leu 468 | - | expression tag |
Phe 469 | - | expression tag |
Gln 470 | - | expression tag |
Gly 471 | - | expression tag |
Pro 472 | - | expression tag |
His 473 | - | expression tag |
His 474 | - | expression tag |
His 475 | - | expression tag |
His 476 | - | expression tag |
His 477 | - | expression tag |
His 478 | - | expression tag |
His 479 | - | expression tag |
His 480 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Lys 1 | - | expression tag |
Thr 2 | - | expression tag |
Ile 3 | - | expression tag |
Ile 4 | - | expression tag |
Ala 5 | - | expression tag |
Leu 6 | - | expression tag |
Ser 7 | - | expression tag |
Tyr 8 | - | expression tag |
Ile 9 | - | expression tag |
Phe 10 | - | expression tag |
Cys 11 | - | expression tag |
Leu 12 | - | expression tag |
Val 13 | - | expression tag |
Phe 14 | - | expression tag |
Ala 15 | - | expression tag |
Asp 16 | - | expression tag |
Tyr 17 | - | expression tag |
Lys 18 | - | expression tag |
Asp 19 | - | expression tag |
Asp 20 | - | expression tag |
Asp 21 | - | expression tag |
Asp 22 | - | expression tag |
Lys 23 | - | expression tag |
His 24 | - | expression tag |
Gly 25 | - | expression tag |
Ser 26 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 184356.0 | |
All* | Total formula weight | 184356.0 |