6E2O
ASK1 kinase domain complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase 5 | polymer | 295 | 33203.7 | 2 | UniProt (Q99683) Pfam (PF00069) | Homo sapiens (Human) | Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5 |
| 2 | C, D (A, B) | 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide | non-polymer | 411.5 | 2 | Chemie (S0L) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B: 659 - 951 (UniProt: Q99683)
| PDB | External Database | Details |
|---|---|---|
| Gly 657 | - | expression tag |
| Ser 658 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66407.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.9 | |
| All* | Total formula weight | 67230.4 |
