6E23
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | WD repeat-containing protein 5 | polymer | 313 | 34391.0 | 2 | UniProt (P61964) Pfam (PF00400) In PDB | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 2 | A, B | N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide | non-polymer | 498.4 | 2 | Chemie (HLJ) | |||
| 3 | B | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | water | water | 18.0 | 533 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68782.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1235.1 | |
| All* | Total formula weight | 70017.0 |
