6E22
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | WD repeat-containing protein 5 | polymer | 313 | 34391.0 | 2 | UniProt (P61964) Pfam (PF00400) In PDB | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 2 | A, B | 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide | non-polymer | 386.4 | 2 | Chemie (HLS) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 887 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68782.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 965.0 | |
| All* | Total formula weight | 69746.9 |
