6DZZ
Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 540 | 61005.1 | 1 | UniProt (P31645) Pfam (PF00209) | Homo sapiens (Human) | SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4 |
| 2 | B (B) | 15B8 antibody heavy chain | polymer | 118 | 12980.5 | 1 | Mus musculus (Mouse) | ||
| 3 | C (C) | 15B8 antibody light chain | polymer | 110 | 11776.1 | 1 | Mus musculus (Mouse) | ||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (A) | (5beta)-12-methoxyibogamine | non-polymer | 310.4 | 1 | Chemie (HJM) | |||
| 6 | F (A) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 85761.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 821.0 | |
| All* | Total formula weight | 87007.1 |
