6DY2
Guinea pig N-acylethanolamine-hydrolyzing acid amidase (NAAA) covalently bound to beta-lactam inhibitor ARN726
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | N-acylethanolamine acid amidase alpha-subunit | polymer | 105 | 11686.4 | 2 | UniProt (H0VCJ6) Pfam (PF15508) In PDB | Cavia porcellus (Guinea pig) | |
2 | B, D | N-acylethanolamine acid amidase beta-subunit | polymer | 233 | 25967.4 | 2 | UniProt (H0VCJ6) In PDB | Cavia porcellus (Guinea pig) | |
3 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
4 | A, B, C, D | CHLORIDE ION | non-polymer | 35.5 | 11 | Chemie (CL) | |||
5 | B, D | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
6 | B, D | (2S)-3-amino-2-{[(4-cyclohexylbutoxy)carbonyl]amino}propanethioic S-acid | non-polymer | 302.4 | 2 | Chemie (HJA) | |||
7 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, C: 28 - 123 (UniProt: H0VCJ6)
B, D: 124 - 356 (UniProt: H0VCJ6)
PDB | External Database | Details |
---|---|---|
Asp 19 | - | expression tag |
Arg 20 | - | expression tag |
His 21 | - | expression tag |
His 22 | - | expression tag |
His 23 | - | expression tag |
His 24 | - | expression tag |
His 25 | - | expression tag |
His 26 | - | expression tag |
Gly 27 | - | expression tag |
Ser 28 | Cys 21 | conflict |
Val 74 | - | insertion |
Glu 95 | Lys 87 | conflict |
PDB | External Database | Details |
---|---|---|
Ala 195 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 75307.6 | |
Non-Polymers* | Number of molecules | 21 |
Total formula weight | 2512.0 | |
All* | Total formula weight | 77819.6 |