6DY2

Guinea pig N-acylethanolamine-hydrolyzing acid amidase (NAAA) covalently bound to beta-lactam inhibitor ARN726

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	N-acylethanolamine acid amidase alpha-subunit	polymer	105	11686.4	2	UniProt (H0VCJ6) Pfam (PF15508)	Cavia porcellus (Guinea pig)
2	B, D (B, D)	N-acylethanolamine acid amidase beta-subunit	polymer	233	25967.4	2	UniProt (H0VCJ6)	Cavia porcellus (Guinea pig)
3	E, F, H, P, Q... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
4	G, J, K, L, M... (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	11	Chemie (CL)
5	I, U (B, D)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
6	O, Y (B, D)	(2S)-3-amino-2-{[(4-cyclohexylbutoxy)carbonyl]amino}propanethioic S-acid	non-polymer		302.4	2	Chemie (HJA)
7	AA, BA, CA, Z (B, C, D, A)	water	water		18.0	133	Chemie (HOH)

Sequence modifications

A, C: 28 - 123 (UniProt: H0VCJ6)

PDB	External Database	Details
Asp 19	-	expression tag
Arg 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
Gly 27	-	expression tag
Ser 28	Cys 21	conflict
Val 74	-	insertion
Glu 95	Lys 87	conflict

B, D: 124 - 356 (UniProt: H0VCJ6)

PDB	External Database	Details
Ala 195	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	75307.6
Non-Polymers*	Number of molecules	21
	Total formula weight	2512.0
All*	Total formula weight	77819.6

*Water molecules are not included.