6DVN
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-137
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hdac6 protein | polymer | 364 | 40285.5 | 4 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (Zebrafish) | |
| 2 | E, K, P, U (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, G, L, M, Q... (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 4 | H, N, S, X (A, B, C, D) | N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-{[4-(hydroxycarbamoyl)phenyl]methyl}benzamide | non-polymer | 460.5 | 4 | Chemie (HB7) | |||
| 5 | I, J, O, T, Y (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | AA, BA, CA, Z (B, C, D, A) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 161141.9 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2726.9 | |
| All* | Total formula weight | 163868.8 |
