6DRX
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5HT2B receptor, BRIL chimera | polymer | 410 | 46049.9 | 1 | UniProt (P41595) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (Human) | 5-HT2B,Serotonin receptor 2B,Cytochrome b-562 |
| 2 | B (A) | N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea | non-polymer | 338.4 | 1 | Chemie (H8G) | |||
| 3 | C (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 4 | D (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) | |||
| 5 | E (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 36 - 248 (UniProt: P41595)
A: 1001 - 1101 (UniProt: P0ABE7)
A: 314 - 404 (UniProt: P41595)
| PDB | External Database | Details |
|---|---|---|
| Trp 144 | Met 144 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | - | linker |
| Gln 1103 | - | linker |
| Lys 1104 | - | linker |
| Tyr 1105 | - | linker |
| Leu 1106 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46049.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1081.6 | |
| All* | Total formula weight | 47131.5 |
