6DM1

Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit	polymer	1031	115178.5	4	UniProt (P19491) UniProt (Q9Y698) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822)	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
2	E, G, I, L (A, B, C, D)	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU)
3	F, H, J, M (A, B, C, D)	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ)
4	K (C)	N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]-2-(naphthalen-1-yl)acetamide	non-polymer		370.5	1	Chemie (GYY)

Sequence modifications

A, B, C, D: 10 - 998 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	conflict
Asp 385	Asn 406	conflict
Gln 392	Asn 413	conflict
Gly 999	-	linker
Thr 1000	-	linker

A, B, C, D: 1001 - 1207 (UniProt: Q9Y698)

PDB	External Database	Details
Asp 1047	Asn 48	conflict
Thr 1208	-	expression tag
Gly 1209	-	expression tag
Gly 1210	-	expression tag
Ala 1211	-	expression tag
Glu 1212	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	460714.1
Non-Polymers*	Number of molecules	9
	Total formula weight	2518.6
All*	Total formula weight	463232.7

*Water molecules are not included.