6DKW
Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase receptor | polymer | 308 | 35101.6 | 2 | UniProt (J3KP20) Pfam (PF07714) UniProt (by SIFTS) (P04629) In PDB | Homo sapiens (Human) | |
2 | A, B | 5-(1-methyl-1H-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide | non-polymer | 502.5 | 2 | Chemie (GXA) | |||
3 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A, B: 502 - 796 (UniProt: J3KP20)
PDB | External Database | Details |
---|---|---|
Met 489 | - | initiating methionine |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
Leu 496 | - | expression tag |
Val 497 | - | expression tag |
Pro 498 | - | expression tag |
Arg 499 | - | expression tag |
Gly 500 | - | expression tag |
Ser 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70203.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1005.0 | |
All* | Total formula weight | 71208.1 |