6DKW

Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase receptor	polymer	308	35101.6	2	UniProt (J3KP20) Pfam (PF07714) UniProt (by SIFTS) (P04629)	Homo sapiens (Human)
2	C, D (A, B)	5-(1-methyl-1H-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide	non-polymer		502.5	2	Chemie (GXA)
3	E, F (A, B)	water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B: 502 - 796 (UniProt: J3KP20)

PDB	External Database	Details
Met 489	-	initiating methionine
His 490	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
Leu 496	-	expression tag
Val 497	-	expression tag
Pro 498	-	expression tag
Arg 499	-	expression tag
Gly 500	-	expression tag
Ser 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70203.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1005.0
All*	Total formula weight	71208.1

*Water molecules are not included.